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A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo. |
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Chen CC, Huang YR, Chan YT, Lin HY, Lin HJ, Hsiao CD, Ko TP, Lin TW, Lan YH, Lin HY, Chang HY*
BMC Biology, 22, 136 (2024-06)
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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein. |
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Liu CY, Cheng HP, Lin CP, Liao YT, Ko TP, Lin SJ, Lin SS, Wang HC*
IUCrJ, 11(Pt 3), 384-394 (2024-05)
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Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α-Galactosidase. |
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Li HY, Lin HY, Chang SK, Chiu YT, Hou CC, Ko TP, Huang KF, Niu DM*, Cheng WC*
JACS Au, 4(3), 908–918 (2024-03)
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Optimization of sequence and chiral content enhances therapeutic potential of tilapia piscidin peptides. |
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Hsu PH, Hazam PK, Huang YP, Yeh JC, Chen YR, Li CC, Chang CF, Liou JW, Chen JY
European Journal of Medicinal Chemistry, 265, 116083 (2024-02)
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Sequential rearrangement and stereochemical reorganization to design an antimicrobial peptide with enhanced stability. |
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Hsu PH, Hazam PK, Huang YP, Yeh JC, Chen YR, Li CC, Chang CF, Liou JW, Chen JY
Biomed Pharmacother, 170, 116088 (2024-01)
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Structure, dynamics and stability of the smallest and most complex 71 protein knot. |
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Hsu MF, Sriramoju MK, Lai CH, Chen YR, Huang JS, Ko TP, Huang KF, Hsu STD*
Journal of Biological Chemistry, 300(1), 105553 (2024-01)
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Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. |
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Yang CS, Ko TP, Chen CJ, Hou MH, Wang YC, Chen Y
Nature Communications, 14, 5078 (2023-08)
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Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. |
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Yeh JC, Hazama PK, Hsieh CY, Hsu PH, Lin WC, Chen YR, Li CC, Chen JY*
Microbiology Spectrum, 11(2), e0385322 (2023-03)
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Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. |
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Hazama PK, Cheng CC, Lin WC, Hsieh CY, Hsu PH, Chen YR, Li CC, Hsueh PR, Chen JY*
European Journal of Medicinal Chemistry, 249, 115131 (2023-01)
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Nickel superoxide dismutase protects nitrogen fixation in Trichodesmium. |
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Chen CC, Rodriguez IB, Chen YL, Zehr JP, Chen YR, Hsu STD, Yang SC, Ho TY*
Limnology and Oceanography Letters, 7(4), 363-371 (2022-08)
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New structural and mechanistic insights into functional roles of cytochrome b 559 in photosystem II.. |
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Chiu YF and Chu HA
Frontiers in Plant Science, 8(13), 914922 (2022-06)
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Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors. |
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Lin CC, Hoo SY, Ma LT, Lin C, Huang KF, Ho YN, Sun CH, Lee HJ, Chen PY, Shu LJ, Wang BW, Hsu WC, Ko TP and Yang YL
Communications Biology, 5(1), 454 (2022-05)
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A Cationic Amphipathic Tilapia Piscidin 4 Peptide-Based Antimicrobial Formulation Promotes Eradication of Bacterial Vaginosis-Associated Bacterial Biofilms. |
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Lin WC, Chen YR, Chuang CM, Chen JY*
Frontiers in Microbiology, 13, 806654 (2022-03)
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Structural insights into the substrate selectivity of α-oxoamine synthases from marine Vibrio sp. QWI-06. |
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Chang HY, Lo LH, Lan YH, Hong MX, Chan YT, Ko TP, Huang YR, Cheng TH, Liaw CC*
Colloids and Surfaces B: Biointerfaces, 210, 112224 (2022-02)
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Crystal structure and functional implication of bacterial STING. |
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Ko TP, Wang YC, Yang CS, Hou MH, Chen CJ, Chiu YF, Chen Y*
Nature Communications, 13(1), 26 (2022-01)
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Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans. |
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
PNAS, 117(3), 1438-1446 (2020-01)
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Untying a knotted SPOUT RNA methyltransferase by circular permutation results in a domain-swapped dimer. |
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Ko KT, Hu IC, Huang KF, Lyu PC, Hsu STD*
STRUCTURE, 27(8), 1224-1233 (2019-08)
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Untying a protein knot by circular permutation. |
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Chuang YC, Hu IC, Lyu PC*, Hsu STD*
JOURNAL OF MOLECULAR BIOLOGY, 431(4), 857-863 (2019-02)
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