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近年來嚴重急性呼吸道症候群（SARS）與中東呼吸道症候群（MERS）的肆虐，以及新興豬冠狀病毒造成的豬隻危害和損失，讓人見識到冠狀病毒對於人類健康與社會經濟的重大影響。 ... Read more
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
PNAS, 117(3), 1438-1446 (2020-01)
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Ko KT, Hu IC, Huang KF, Lyu PC, Hsu STD*
STRUCTURE, 27(8), 1224-1233 (2019-08)
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Chuang YC, Hu IC, Lyu PC*, Hsu STD*
JOURNAL OF MOLECULAR BIOLOGY, 431(4), 857-863 (2019-02)
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2020/10/29 9:00加拿大渥太華大學 李志遠教授主講 “CTSTA Webinar: Targeting membrane proteins as a therapeutic and pharmaceutical vehicle."
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Membrane proteins consist of 25-30% coding genes in typical genomes and account about half of drug target in the R&D of biotech and pharmaceutical industry. In addition, membrane proteins have been shown to channel or translocate metabolites or bioactive small molecules in our bodies, which make it possible to exploit membrane proteins in both drug discovery and delivery. To do so, it is essential to know the mechanisms of target membrane proteins, and the key lies in the understanding of their structure-function relationship. In this webinar, I will discuss plans of our ongoing projects in understanding the mechanism of two medically important membrane proteins in trafficking cholesterol and RNA/DNA oligos. The first objective of this webinar is to discuss how we will utilize the knowledge through basic research of membrane proteins to enable therapeutic and pharmaceutical applications. Secondly, through this forum, we want to share our work in Canada, establish and strengthen future collaborations with Taiwanese colleagues.
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